Dr. Dan Evans and colleagues at CPMCRI and the San Francisco Coordinating Center are using high-throughput genotyping and sequencing methods to study age-related diseases. Their research focuses on three areas:
Genome-wide association studies (GWAS) of osteoarthritis to identify genetic variants associated with this condition, which affects approximately 40% of people aged 70 and older. Projects are underway to uncover the functional impact of associated genetic variants, which will help shed light on the biological processes underlying osteoarthritis.
Identification of genetic variants associated with sleep traits: Changes in the timing and quality of sleep occur as humans age. A highly conserved set of genes, termed “clock genes,” regulate circadian processes including sleep in diverse organisms. Dr. Evans and colleagues found that genetic variants in clock genes are associated with sleep timing and quality in the elderly. They are investigating the relationship between clock gene variants and other age-related traits to better understand the connection between circadian biology and aging.
Understanding and comparing population-specific genetic variation in complex human traits. Most GWAS have been conducted in European populations; performing GWAS in non-European populations can help identify novel genetic associations due to population-specific genetic variation. Dr. Evans’ cross-population studies focus on complex heritable quantitative traits related to heart function, specifically the conduction of excitatory electrical signals.

Sutter Health Research Enterprise
185 Berry Street Lobby 5, Suite 5700
San Francisco, CA, 94107
(415) 600-7432  
evansds@cpmcri.org